Orlistat is administered orally three times a day during high-fat meals. Try to divide your daily intake of fats, carbohydrates and protein evenly between meals. It is recommended to complement the medication with a daily multivitamin supplement, as Orlistat can impede the absorption of fat-soluble vitamins (e.g., A, D, E or K). However, the supplement should be taken 2 hours before or after taking Orlistat. It may take only 1 or 2 days for the first effects of the medication to appear; however, significant weight loss will take longer.